SB-237376

SB-237376 is a blocker of potassium and calcium channels. SB-237376 inhibits the rapidly activating delayed rectifier potassium current I (Kr) (IC50: 0.42 μM) and blocks the L-type calcium current I (Ca, L) at high concentrations[1].

Product Specifications

CAS Number

[179258-62-9]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sb-237376.html

Smiles

COC1=C(OC)C=C(CCNCCCNC(C2=CC=C([N+]([O-])=O)C=C2)=O)C=C1.Cl

Molecular Formula

C20H26ClN3O5

Molecular Weight

423.89

References & Citations

[1]Xu X, et al. Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action. J Cardiovasc Pharmacol. 2003 Mar;41 (3) :414-21.