Antiproliferative agent-54
Antiproliferative agent-54 (Compound 6z) is the inhibitor for multiple kinases, such as ABL WT, B-RAF, EGFR, HCK, LYN A and SRC with IC50 of 6-50 nM. Antiproliferative agent-54 inhibits proliferation of several cancer cell, inhibits HUVEC and HepG2, with EC50 of 34 and 38 nM. Antiproliferative agent-54 exhibits good pharmacokinetic characteristics in rats[1].
Product Specifications
CAS Number
1240322-54-6
UNSPSC
12352005
Target
EGFR; Raf; Src; VEGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antiproliferative-agent-54.html
Smiles
O=C(C1=CC2=CC(NCC3=CC(NC(C4=CC(C(F)(F)F)=CC(N5C=C(C)N=C5)=C4)=O)=CC=C3C)=CN=C2N1)OC
Molecular Formula
C29H25F3N6O3
Molecular Weight
562.54
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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