Anticancer agent 253

Anticancer agent 253 (Compound 26) has anti-cancer activity against breast cancer cells, with IC50s of 6 μM (MCF-7), 10 μM (MDA-MB-231) and 6.4 μM (4T1 cells) . Anticancer agent 253 arrests cell cycle and induces mitochondria-mediated apoptosis in cancer cells. Anticancer agent 253 inhibits Akt phosphorylation in human breast and prostate cancer[1].

Product Specifications

CAS Number

[1983924-33-9]

UNSPSC

12352005

Target

Akt; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-253.html

Smiles

O=C(/C(CN(C/1)CC2=CN(N=N2)CC3=CC=C(C=C3)F)=C/C4=C(C=CC=C4)F)C1=C\C5=C(C=CC=C5)F

Molecular Formula

C29H23F3N4O

Molecular Weight

500.51

References & Citations

[1]Mandalapu D, et al. Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines. Bioorg Med Chem Lett. 2016 Sep 1;26 (17) :4223-32.