ITD-1

ITD-1 is the first selective TGFβ receptor inhibitor with an IC50 of 460 nM.

Product Specifications

CAS Number

[1099644-42-4]

UNSPSC

12352005

Hazard Statement

H302

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ITD-1.html

Concentration

10mM

Purity

99.41

Solubility

DMSO : 28 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=C(C)NC2=C(C(CC(C)(C)C2)=O)C1C3=CC=C(C4=CC=CC=C4)C=C3)OCC

Molecular Formula

C27H29NO3

Molecular Weight

415.52

Precautions

H302

References & Citations

[1]Willems E, et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11 (2) :242-52.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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