ITD-1
ITD-1 is the first selective TGFβ receptor inhibitor with an IC50 of 460 nM.
Product Specifications
CAS Number
[1099644-42-4]
UNSPSC
12352005
Hazard Statement
H302
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ITD-1.html
Concentration
10mM
Purity
99.41
Solubility
DMSO : 28 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=C(C)NC2=C(C(CC(C)(C)C2)=O)C1C3=CC=C(C4=CC=CC=C4)C=C3)OCC
Molecular Formula
C27H29NO3
Molecular Weight
415.52
Precautions
H302
References & Citations
[1]Willems E, et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11 (2) :242-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12704/ITD-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12704/ITD-1-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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