CDK4/6-IN-21 (maleate)

CDK4/6-IN-21 maleate (compound I-52) is a CDK4/6 inhibitor with IC50 values of 3.88 and 3.31 nM for CDK4 and CDK6, respectively. CDK4/6-IN-21 maleate has antitumor activity[1].

Product Specifications

CAS Number

[2765997-88-2]

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk4-6-in-21-maleate.html

Smiles

OC(/C=C\C(O)=O)=O.CC(N(C1CC1)C2=CC(C3=NC(NC4=CC=C(CN(CC5)CCN(C)C)C5=N4)=NC=C3F)=C6)=NC2=C6F

Molecular Formula

C31H34F2N8O4

Molecular Weight

620.65

References & Citations

[1]Guangxin Xia J, et al. Nitrogen-containing fused heterocyclic compound, as well as preparation method, intermediate, composition and application thereof. WO2017114512A1. 2017-07-06.