CDK4/6-IN-21 (maleate)
CDK4/6-IN-21 maleate (compound I-52) is a CDK4/6 inhibitor with IC50 values of 3.88 and 3.31 nM for CDK4 and CDK6, respectively. CDK4/6-IN-21 maleate has antitumor activity[1].
Product Specifications
CAS Number
[2765997-88-2]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk4-6-in-21-maleate.html
Smiles
OC(/C=C\C(O)=O)=O.CC(N(C1CC1)C2=CC(C3=NC(NC4=CC=C(CN(CC5)CCN(C)C)C5=N4)=NC=C3F)=C6)=NC2=C6F
Molecular Formula
C31H34F2N8O4
Molecular Weight
620.65
References & Citations
[1]Guangxin Xia J, et al. Nitrogen-containing fused heterocyclic compound, as well as preparation method, intermediate, composition and application thereof. WO2017114512A1. 2017-07-06.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6
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