Human RAF1 (EE) Active

<strong>Human RAF1 (EE) Active</strong>_x000D_ <strong>Catalog number:</strong> B2013617_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 63 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20¬∞C_x000D_ <strong>Keywords:</strong> RAF1 (EE) (306-end)_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Garcia-Alonso S, Mesa P, Ovejero LP, Aizpurua G, Lechuga CG, Zarzuela E, Santiveri CM, Sanclemente M, Mauro J, Musteanu M, Campos-Olivas R, Marti¬≠nez-Torrecuadrada J, Barbacid M, Montoya G. Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation Mol Cell. 2022 Sep 15;82(18):3438-3452.e8._x000D_ 2: Luo X, Liu H, Guo H, Sun L, Gou K, Cui S. RAF1 mediates the FSH signaling pathway as a downstream molecule to stimulate estradiol synthesis and secretion in mouse ovarian granulosa cells Ann Transl Med. 2022 Mar;10(6):314._x000D_ 3: Prall OWJ, Nastevski V, Xu H, McEvoy CRE, Vissers JHA, Byrne DJ, Takano E, Yerneni S, Ellis S, Green T, Mitchell CA, Murray WK, Scott CL, Grimmond SM, Hofmann O, Papenfuss A, Kee D, Fellowes A, Brown IS, Miller G, Kumarasinghe MP, Perren A, Nahm CB, Mittal A, Samra J, Ahadi M, Fox SB, Chou A, Gill AJ. RAF1 rearrangements are common in pancreatic acinar cell carcinomas Mod Pathol. 2020 Sep;33(9):1811-1821._x000D_ 4: Li Y, Pan M, Lu T, Yu D, Liu C, Wang Z, Hu G. RAF1 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating LAGE1: an experimental research J Transl Med. 2022 Jun 6;20(1):255._x000D_ 5: Yu W, Zheng Z, Wei W, Li L, Zhang Y, Sun Y, Cao J, Zang W, Shao J. Raf1 interacts with OIP5 to participate in oxaliplatin-induced neuropathic pain Life Sci. 2021 Sep 15;281:119804._x000D_ 6: Guo C, Xu H, Zhou Y, Wu Z, Jiang B, Chen H, Lin D. Cefotetan-bound human RKIP involves in Ras/Raf1/MEK/ERK signaling pathway Acta Biochim Biophys Sin (Shanghai). 2022 Dec 25;54(12):1917-1923._x000D_ 7: Bekele RT, Samant AS, Nassar AH, So J, Garcia EP, Curran CR, Hwang JH, Mayhew DL, Nag A, Thorner AR, Baresark J, Sztupinszki Z, Pan CX, Bellmunt J, Kwiatkowski DJ, Sonpavde GP, Van Allen EM, Mouw KW. RAF1 amplification drives a subset of bladder tumors and confers sensitivity to MAPK-directed therapeutics J Clin Invest. 2021 Nov 15;131(22):e147849._x000D_ 8: Clark-Garvey S, Kim WY. RAF1 amplification: an exemplar of MAPK pathway activation in urothelial carcinoma J Clin Invest. 2021 Nov 15;131(22):e154095._x000D_ 9: Rankin A, Johnson A, Roos A, Kannan G, Knipstein J, Britt N, Rosenzweig M, Haberberger J, Pavlick D, Severson E, Vergilio JA, Squillace R, Erlich R, Sathyan P, Cramer S, Kram D, Ross J, Miller V, Reddy P, Alexander B, Ali SM, Ramkissoon S. Targetable BRAF and RAF1 Alterations in Advanced Pediatric Cancers Oncologist. 2021 Jan;26(1):e153-e163._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/32123303">10: Williams EA, Shah N, Montesion M, Sharaf R, Pavlick DC, Sokol ES, Alexander BM, Venstrom JM, Elvin JA, Ross JS, Tse JY, Mochel MC. Melanomas with activating RAF1 fusions: clinical, histopathologic, and molecular profiles Mod Pathol. 2020 Aug;33(8):1466-1474. </a>_x000D_ _x000D_ <strong>Products Related to Human RAF1 (EE) Active can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>