(S, R, S) -AHPC-C4-COOH

(S, R, S) -AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and a linker used for EED-targeted PROTAC[1].

Product Specifications

CAS Number

[2172819-74-6]

Product Name Alternative

VH032-C4-COOH

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-c4-cooh.html

Purity

95.92

Solubility

10 mM in DMSO

Smiles

OC(CCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O)=O

Molecular Formula

C28H38N4O6S

Molecular Weight

558.69

Precautions

H302, H315, H319

References & Citations

[1]Liu Jing, et al. Preparation of pyrazolopyridines and related heterocycles as CBP and p300 degradation bivalent compds for treatment of diseases. World Intellectual Property Organization, WO2020173440 A1 2020-09-03