(S, R, S) -AHPC-C4-COOH
(S, R, S) -AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and a linker used for EED-targeted PROTAC[1].
Product Specifications
CAS Number
2172819-74-6
Product Name Alternative
VH032-C4-COOH
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-c4-cooh.html
Purity
95.92
Solubility
10 mM in DMSO
Smiles
OC(CCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O)=O
Molecular Formula
C28H38N4O6S
Molecular Weight
558.69
Precautions
H302, H315, H319
References & Citations
[1]Liu Jing, et al. Preparation of pyrazolopyridines and related heterocycles as CBP and p300 degradation bivalent compds for treatment of diseases. World Intellectual Property Organization, WO2020173440 A1 2020-09-03
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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