CPSA

CPSA is a potent and competitive inhibitor against 20α-hydroxysteroid dehydrogenase (AKR1C1) with a Ki value of 0.86 nM. CPSA is promising for research of lung and endometrial cancers, premature birth and neuronal disorders[1].

Product Specifications

CAS Number

[1038713-54-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Aldose Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cpsa.html

Smiles

O=C(C1=CC(C2=CC=CC=C2)=CC(Cl)=C1O)O

Molecular Formula

C13H9ClO3

Molecular Weight

248.66

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]El-Kabbani O, et al. Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis. Bioorg Med Chem Lett. 2011 Apr 15;21 (8) :2564-7.