Ibrutinib-d5
Ibrutinib-d5 (PCI-32765-d5) is a deuterium labeled Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor[1].
Product Specifications
Product Name Alternative
PCI-32765-d5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Btk
Type
Isotope-Labeled Compounds
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.08
Solubility
10 mM in DMSO|DMF : ≥ 30mg/mL|DMSO : ≥ 30mg/mL|Ethanol : ≥ 0.25mg/mL
Smiles
C=CC(N1C[C@H](N2N=C(C3=CC=C(OC4=C([2H])C([2H])=C([2H])C([2H])=C4[2H])C=C3)C5=C(N)N=CN=C52)CCC1)=O
Molecular Formula
C25H19D5N6O2
Molecular Weight
445.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107 (29) :13075-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10997S/Ibrutinib-d5-SDS-MedChemExpress.pdf
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
CAS Number
[1553977-17-5]
Available Sizes
Curated Selection
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