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Dihydromunduletone

Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC 50 of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs[1].

Product Specifications

CAS Number

674786-20-0

UNSPSC

12352005

Target

Drug Derivative; Orphan Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Dihydromunduletone.html

Concentration

10mM

Purity

99.23

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC1(C)C=CC2=C(OC)C(CC(C3=C(O)C=C4C(CC(O)C(C)(C)O4)=C3)=O)=CC=C2O1

Molecular Formula

C25H28O6

Molecular Weight

424.49

References & Citations

[1]Hannah M. Stoveken, et al. Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein–Coupled Receptor Antagonist. Mol Pharmacol. 2016 Sep; 90 (3) : 214–224.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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