GW 610

GW 610 (NSC 721648), an antitumor agent, is a potent AhR ligand with a Ki of 6.8 nM. GW 610 induces CYP1A1 expression in MCF-7 cells. GW 610 shows potent and selective anticancer activity against lung, colon, and breast cancer cell lines[1].

Product Specifications

CAS Number

[872726-44-8]

Product Name Alternative

NSC 721648

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Aryl Hydrocarbon Receptor; Cytochrome P450

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gw-610.html

Purity

99.78

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC=C(SC(C2=CC=C(OC)C(OC)=C2)=N3)C3=C1

Molecular Formula

C15H12FNO2S

Molecular Weight

289.32

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Mortimer CG, et, al. Antitumor benzothiazoles. 26. (1) 2- (3,4-dimethoxyphenyl) -5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines. J Med Chem. 2006 Jan 12;49 (1) :179-85.|[2]Aiello S, et, al. Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2- (3,4-dimethoxyphenyl) -5-fluorobenzothiazole (PMX 610, NSC 721648) . J Med Chem. 2008 Aug 28;51 (16) :5135-9.|[3]Tan BS, et, al. CYP2S1 and CYP2W1 mediate 2- (3,4-dimethoxyphenyl) -5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells. Mol Cancer Ther. 2011 Oct;10 (10) :1982-92.|[4]Boon Shing Tan, et al. CYP2S1 and CYP2W1 mediate 2- (3,4-dimethoxyphenyl) -5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells. Mol Cancer Ther. 2011 Oct;10 (10) :1982-92.