α-Conotoxin MII (TFA)

α-Conotoxin MII TFA (α-CTxMII TFA), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII TFA (α-CTxMII TFA) potently blocks β3-containing neuronal nicotinic receptors [1][2][3].

OC(C(F)(F)F)=O.O=C(N[C@@H](CSSC[C@@H](C(N)=O)NC1=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@H]1CC(C)C)=O)=O)=O)=O)=O)=O)=O)NC4=O)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N5[C@@H](CCC5)C(N[C@H]4C(C)C)=O)=O)=O)=O)=O)CN

[1]G E Cartier, et al. A New Alpha-Conotoxin Which Targets alpha3beta2 Nicotinic Acetylcholine Receptors. J Biol Chem. 1996 Mar 29;271(13):7522-8.|[2]S C Harvey, et al. Determinants of Specificity for Alpha-Conotoxin MII on alpha3beta2 Neuronal Nicotinic Receptors. Mol Pharmacol. 1997 Feb;51(2):336-42.|[3]J M McIntosh, et al. Conus Peptides: Novel Probes for Nicotinic Acetylcholine Receptor Structure and Function. Eur J Pharmacol. 2000 Mar 30;393(1-3):205-8.