ER176
ER176 is a next generation PET radioligand for imaging 18 kDa translocator protein (TSPO), a biomarker for neuroinflammation[1][2].
Product Specifications
CAS Number
[1373887-29-6]
Product Name Alternative
BIBD-239
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/er176.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NC(C2=CC=CC=C2Cl)=C3C=CC=CC3=N1)N(C)[C@H](C)CC
Molecular Formula
C20H20ClN3O
Molecular Weight
353.85
References & Citations
[1]Masahiro Fujita, et al. Comparison of four 11 C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R) -PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios. EJNMMI Res. 2017 Oct 16;7 (1) :84.|[2]Jason C Mixdorf, et al. Alternative strategies for the synthesis of [ 11 C]ER176 for PET imaging of neuroinflammation. Appl Radiat Isot. 2021 Sep 17;178:109954.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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