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5-FAM-Dyrktide

5-FAM-Dyrktide is a 5-FAM labeled Dyrktide. Dyrktide, a substrate, is efficiently phosphorylated by DYRK1A (Km=35 μM) but not by ERK2[1][2].

Product Specifications

UNSPSC

12352209

Target

DYRK; Fluorescent Dye

Type

Peptides

Related Pathways

Others; Protein Tyrosine Kinase/RTK

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5-fam-dyrktide.html

Solubility

10 mM in DMSO

Smiles

O=C1OC2(C3=C1C=C(C=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N4[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(N[C@H](C(NCC(N6[C@H](C(N7[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCC7)=O)CCC6)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCC5)=O)CO)=O)C)=O)CCC4)=O)CCCNC(N)=N)=O)CC8=CC=CC=C8)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C9=C(C=C(C=C9)O)OC%10=C2C=CC(O)=C%10

Molecular Formula

C100H145N31O23

Molecular Weight

2149.42

References & Citations

[1]S Himpel, et al. Specificity determinants of substrate recognition by the protein kinase DYRK1A. J Biol Chem. 2000 Jan 28;275 (4) :2431-8.|[2]Kevin D Freeman-Cook, et al. Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J Med Chem. 2021 Jul 8;64 (13) :9056-9077.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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