BTK degrader-1
BTK degrader-1 (compound 1) is a Bruton’s tyrosine kinase (BTK) bifunctional degrader that can be conjugated with CD79b. BTK degrader-1 (compound 1) has anti-tumor effect[1].
Product Specifications
CAS Number
[2377645-56-0]
UNSPSC
12352005
Target
ADC Payload; Btk
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btk-degrader-1.html
Purity
99.40
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C(C)(C)O)C=C1F)NC2=CC(F)=CC(C3=C4C=C(C5=CC=C(CCN6CCC7(CC6)CCN(CC7)C(C8=CC=C(C(N9C(NC(CC9)=O)=O)=C8)OC)=O)C=C5)NC4=NC=N3)=C2C
Molecular Formula
C52H54F2N8O6
Molecular Weight
925.03
References & Citations
[1]Alan Zhang, et al. Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79bTargeted Antibody–Drug Conjugates. Bioconjug Chem. 2024 Feb 21;35 (2) :140-146.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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