BTK degrader-1

BTK degrader-1 (compound 1) is a Bruton’s tyrosine kinase (BTK) bifunctional degrader that can be conjugated with CD79b. BTK degrader-1 (compound 1) has anti-tumor effect[1].

Product Specifications

CAS Number

[2377645-56-0]

UNSPSC

12352005

Target

ADC Payload; Btk

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/btk-degrader-1.html

Purity

99.40

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C(C)(C)O)C=C1F)NC2=CC(F)=CC(C3=C4C=C(C5=CC=C(CCN6CCC7(CC6)CCN(CC7)C(C8=CC=C(C(N9C(NC(CC9)=O)=O)=C8)OC)=O)C=C5)NC4=NC=N3)=C2C

Molecular Formula

C52H54F2N8O6

Molecular Weight

925.03

References & Citations

[1]Alan Zhang, et al. Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79bTargeted Antibody–Drug Conjugates. Bioconjug Chem. 2024 Feb 21;35 (2) :140-146.