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Lomefloxacin (hydrochloride)

Lomefloxacin hydrochloride (NY-198 hydrochloride) is an orally active difluoroquinolone antibiotic. Lomefloxacin hydrochloride prevents DNA supercoiling and replication by inhibiting bacterial topoisomerase II. Lomefloxacin hydrochloride induces ROS production and Apoptosis. Lomefloxacin hydrochloride has broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Lomefloxacin hydrochloride has anticancer effects against melanoma. Lomefloxacin hydrochloride can be used in the study of systemic bacterial infections (such as Salmonella typhimurium infections), skin and melanoma [1][2][3][4][5][6].

Product Specifications

CAS Number

98079-52-8

Product Name Alternative

SC47111A (hydrochloride) ; NY-198 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Apoptosis; Bacterial; Reactive Oxygen Species (ROS) ; Topoisomerase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Endocrinology

Assay Protocol

https://www.medchemexpress.com/lomefloxacin-hydrochloride.html

Purity

99.97

Solubility

H2O : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCN(C=C(C(O)=O)C1=O)C(C1=CC(F)=C2N(CCN3)CC3C)=C2F.Cl

Molecular Formula

C17H20ClF2N3O3

Molecular Weight

387.81

Precautions

H302, H315, H319, H335

References & Citations

[1]Hirose T, et al. In vitro and in vivo activity of NY-198, a new difluorinated quinolone. Antimicrob Agents Chemother. 1987 Jun;31 (6) :854-9. |[2]Piddock LJ, et al. Mechanism of action of lomefloxacin. Antimicrob Agents Chemother. 1990 Jun;34 (6) :1088-93.|[3]Beberok A, et al. Lomefloxacin Induces Oxidative Stress and Apoptosis in COLO829 Melanoma Cells. Int J Mol Sci. 2017 Oct 20;18 (10) :2194.|[4]Marrot L, et al. Molecular responses to photogenotoxic stress induced by the antibiotic lomefloxacin in human skin cells: from DNA damage to apoptosis. J Invest Dermatol. 2003 Sep;121 (3) :596-606. |[5]Butler T, et al. Treatment of experimental Salmonella typhimurium infection in mice with lomefloxacin. J Antimicrob Chemother. 1990 Apr;25 (4) :629-34.|[6]Singh AC, et al. Genotoxicity of lomefloxacin--an antibacterial drug in somatic and germ cells of Swiss albino mice in vivo. Mutat Res. 2003 Feb 5;535 (1) :35-42.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Quinolone

Available Sizes

Frequently Asked Questions

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