Human CDK4 Protein

<strong>Human CDK4 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011909_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 36.1 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> CMM3 protein, CDK4, CDK 4 protein, CDK 4, PSK-J3 protein, CDK-4, Cyclin-dependent kinase 4 protein, CDK-4 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Braal CL, Jongbloed EM, Wilting SM, Mathijssen RHJ, Koolen SLW, Jager A. Inhibiting CDK4/6 in Breast Cancer with Palbociclib, Ribociclib, and Abemaciclib: Similarities and Differences Drugs. 2021 Feb;81(3):317-331._x000D_ 2: Gao X, Leone GW, Wang H. Cyclin D-CDK4/6 functions in cancer Adv Cancer Res. 2020;148:147-169._x000D_ 3: Goel S, DeCristo MJ, McAllister SS, Zhao JJ. CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest Trends Cell Biol. 2018 Nov;28(11):911-925._x000D_ 4: Suski JM, Braun M, Strmiska V, Sicinski P. Targeting cell-cycle machinery in cancer Cancer Cell. 2021 Jun 14;39(6):759-778._x000D_ 5: Pandey K, An HJ, Kim SK, Lee SA, Kim S, Lim SM, Kim GM, Sohn J, Moon YW. Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review Int J Cancer. 2019 Sep 1;145(5):1179-1188._x000D_ 6: Álvarez-Fernández M, Malumbres M. Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition Cancer Cell. 2020 Apr 13;37(4):514-529._x000D_ 7: Goel S, Bergholz JS, Zhao JJ. Targeting CDK4 and CDK6 in cancer Nat Rev Cancer. 2022 Jun;22(6):356-372._x000D_ 8: Ingham M, Schwartz GK. Cell-Cycle Therapeutics Come of Age J Clin Oncol. 2017 Sep 1;35(25):2949-2959._x000D_ 9: Yin Q, Jian Y, Xu M, Huang X, Wang N, Liu Z, Li Q, Li J, Zhou H, Xu L, Wang Y, Yang C. CDK4/6 regulate lysosome biogenesis through TFEB/TFE3 J Cell Biol. 2020 Aug 3;219(8):e201911036._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/30389903">10: Portman N, Alexandrou S, Carson E, Wang S, Lim E, Caldon CE. Overcoming CDK4/6 inhibitor resistance in ER-positive breast cancer Endocr Relat Cancer. 2019 Jan;26(1):R15-R30. </a>_x000D_ _x000D_ <strong>Products Related to Human CDK4 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>