Dehydrocorydaline (chloride)
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities[2]. Dehydrocorydaline chloride shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain[3].
Product Specifications
CAS Number
10605-03-5
Product Name Alternative
13-Methylpalmatine (chloride)
UNSPSC
12352005
Hazard Statement
H301, H315
Target
Autophagy; Bcl-2 Family; Caspase; p38 MAPK; Parasite; PARP
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Dehydrocorydaline-chloride.html
Purity
99.75
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OC)=C(OC)C=C4CC3.[Cl-]
Molecular Formula
C22H24ClNO4
Molecular Weight
401.88
Precautions
H301, H315
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium
Citation 01
Available Sizes
Frequently Asked Questions
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