Piperulin A
Piperulin A is a potent inhibitor of PAFR. Piperulin A inhibits the specific binding of PAFR on isolated rabbit platelet plasma membranes with an IC50 of 7.3 μM[1].
Product Specifications
CAS Number
164268-04-6
UNSPSC
12352005
Target
Platelet-activating Factor Receptor (PAFR)
Type
Natural Products
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/piperulin-a.html
Solubility
10 mM in DMSO
Smiles
CO[C@@]([C@H]1C)(C=C2CC=C)[C@H]([C@@](C2=O)([H])[C@H]1C(C=C3)=CC(OC)=C3OC)OC(C)=O
Molecular Formula
C23H28O6
Molecular Weight
400.46
References & Citations
[1]Zhang SX, et al. The isolation and structural elucidation of three new neolignans, piperulins [corrected] A, B, and C, as platelet activating factor receptor antagonists from Piper puberulum. J Nat Prod. 1995 Apr;58 (4) :540-7.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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