Piperulin A

Piperulin A is a potent inhibitor of PAFR. Piperulin A inhibits the specific binding of PAFR on isolated rabbit platelet plasma membranes with an IC50 of 7.3 μM[1].

Product Specifications

CAS Number

[164268-04-6]

UNSPSC

12352005

Target

Platelet-activating Factor Receptor (PAFR)

Type

Natural Products

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/piperulin-a.html

Solubility

10 mM in DMSO

Smiles

CO[C@@]([C@H]1C)(C=C2CC=C)[C@H]([C@@](C2=O)([H])[C@H]1C(C=C3)=CC(OC)=C3OC)OC(C)=O

Molecular Formula

C23H28O6

Molecular Weight

400.46

References & Citations

[1]Zhang SX, et al. The isolation and structural elucidation of three new neolignans, piperulins [corrected] A, B, and C, as platelet activating factor receptor antagonists from Piper puberulum. J Nat Prod. 1995 Apr;58 (4) :540-7.