L-765314
L-765314 is a potent and selective α1b adrenergic receptor antagonist with Kis of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.
Product Specifications
CAS Number
189349-50-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/L-765314.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1[C@H](C(NC(C)(C)C)=O)CN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)OCC4=CC=CC=C4
Molecular Formula
C27H34N6O5
Molecular Weight
522.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Patane MA, et al. 4-Amino-2-[4-[1- (benzyloxycarbonyl) -2 (S) - [[ (1,1-dimethylethyl) amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314) : a potent and selective alpha1b adrenergic receptor antagonist. J Med Chem. 1998 Apr 9;41 (8) :1205-8.|[2]Tobias Böhmer, et al. The α1B-adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium. Br J Pharmacol. 2014 Aug; 171 (16) : 3858–3867.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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