L-765314

L-765314 is a potent and selective α1b adrenergic receptor antagonist with Kis of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.

Product Specifications

CAS Number

[189349-50-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/L-765314.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1[C@H](C(NC(C)(C)C)=O)CN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)OCC4=CC=CC=C4

Molecular Formula

C27H34N6O5

Molecular Weight

522.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Patane MA, et al. 4-Amino-2-[4-[1- (benzyloxycarbonyl) -2 (S) - [[ (1,1-dimethylethyl) amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314) : a potent and selective alpha1b adrenergic receptor antagonist. J Med Chem. 1998 Apr 9;41 (8) :1205-8.|[2]Tobias Böhmer, et al. The α1B-adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium. Br J Pharmacol. 2014 Aug; 171 (16) : 3858–3867.