EpCAM Recombinant Rabbit Monoclonal Antibody [PS01-69]
EPCAM is a carcinoma-associated antigen and belongs to a family which includes at least 2 type I membrane proteins. The EPCAM protein has a role in embryonic stem cells proliferation and differentiation. EPCAM is used as a target for immunotherapy treatment of human carcinomas. EPCAM is expressed on most normal epithelial cells and gastrointestinal carcinomas and acts as a homotypic calcium-independent cell adhesion molecule. Epithelial cell adhesion molecules (EPCAM) can act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for supplying immunological barrier as a first line of defense against mucosal infection. EPCAM gene mutations result in congenital tufting enteropathy.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Ep-CAM, EGP, EGP314, hEGP314, EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
Swiss Prot
P16422 Human
Cellular Locus
Lateral cell membrane, Cell junction.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide.
Isotype
IgG
Clone
PS01-69
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
IHC-P, IF-Cell, FC
Positive Control
Human colon tissue, HT-29.
Concentration
1 mg/mL
Dilution
IHC-P: 1:200 ;IF-Cell: 1:100 ;FC: 1:500-1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 35 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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