A-1293201
A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total cellular NAD+/NADH (NADt) level, subsequently leading to ATP depletion and cancer cell death. In addition, A-1293201 can effectively overcome the acquired resistance mechanism of the NAMPT Y18 mutant to CHS-828.
Product Specifications
CAS Number
1375557-33-7
UNSPSC
12352005
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a-1293201.html
Purity
99.82
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(N1CC2=C(C=CC=C2)C1)NC3=CC=C(C(NC[C@H]4COCC4)=O)C=C3
Molecular Formula
C21H23N3O3
Molecular Weight
365.43
References & Citations
[1]Jun Guo, et al. "Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation." Biochemical and biophysical research communications 491.3 (2017) : 681-686.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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