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A-1293201

A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total cellular NAD+/NADH (NADt) level, subsequently leading to ATP depletion and cancer cell death. In addition, A-1293201 can effectively overcome the acquired resistance mechanism of the NAMPT Y18 mutant to CHS-828.

Product Specifications

CAS Number

1375557-33-7

UNSPSC

12352005

Target

NAMPT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/a-1293201.html

Purity

99.82

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(N1CC2=C(C=CC=C2)C1)NC3=CC=C(C(NC[C@H]4COCC4)=O)C=C3

Molecular Formula

C21H23N3O3

Molecular Weight

365.43

References & Citations

[1]Jun Guo, et al. "Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation." Biochemical and biophysical research communications 491.3 (2017) : 681-686.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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