RdRP-IN-8
RdRP-IN-8 (compound 45) is an anti-influenza virus compound. RdRP-IN-8 inhibits viral RNA-dependent RNA polymerase (RdRP) activity by disrupting heterodimerization of PA and PB1 subunits (EC50=0.13 μM) [1].
Product Specifications
UNSPSC
12352005
Target
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/rdrp-in-8.html
Smiles
O=C(C1=C(O)C=C([N+]([O-])=O)C=C1)NC(S2)=C(C(NC3=CC=CC=C3O)=O)C4=C2CCCCC4
Molecular Formula
C23H21N3O6S
Molecular Weight
467.49
References & Citations
[1]Bonomini, et al. "Optimization of Potent, Broad-spectrum, and Specific Anti-influenza Compounds Targeting RNA Polymerase PA-PB1 heterodimerization." European Journal of Medicinal Chemistry (2024) : 116737.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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