N-Desethyl amodiaquine dihydrochloride

N-Desethyl amodiaquine dihydrochloride is the biologically active metabolite of Amodiaquine (HY-B1322A) . N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine dihydrochloride can be used for the research of malaria[1][2].

Product Specifications

CAS Number

[79049-30-2]

UNSPSC

12352005

Hazard Statement

H225, H301+H311+H331, H370

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/n-desethyl-amodiaquine-dihydrochloride.html

Purity

99.88

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1CNCC.Cl.Cl

Molecular Formula

C18H20Cl3N3O

Molecular Weight

400.73

Precautions

H225, H301+H311+H331, H370

References & Citations

[1]Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199 (11) :1575-82.|[2]Xue-Qing Li, et al. Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300 (2) :399-407.