(E/Z) -Teriflunomide
(E/Z) -Teriflunomide ((E/Z) -A77 1726) is the active metabolite of Leflunomide (HY-B0083) . Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) . Leflunomide can be used for the research of rheumatoid arthritis (RA) [1].
Product Specifications
CAS Number
[108605-62-5]
Product Name Alternative
(E/Z) -A77 1726
UNSPSC
12352005
Hazard Statement
H301, H312, H330, H410
Target
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/e-z-teriflunomide.html
Purity
99.87
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21
Precautions
H301, H312, H330, H410
References & Citations
[1]R I Fox, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93 (3) :198-208.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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