VUF10132
Product Specifications
UNSPSC Description
VUF10132 is a non-peptide CXCR3 receptor antagonist with anti-inflammatory activity, inhibiting diseases such as rheumatoid arthritis, multiple sclerosis, and psoriasis. VUF10132 has high affinity for the human CXCR3 receptor but slightly lower affinity for the murine CXCR3 receptor. Additionally, VUF10132 exhibits inverse agonist properties at the CXCR3 receptor[1].
Target Antigen
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vuf10132.html
Smiles
O=C(CN1C=[N+](C=C1)CC(C2=CC=C(C(Cl)=C2)Cl)=O)C3=CC=C(C(Cl)=C3)Cl.[Br-]
Molecular Weight
523.03
References & Citations
[1]Noncompetitive Antagonism and Inverse Agonism as Mechanism of Action of Nonpeptidergic Antagonists at Primate and Rodent CXCR3 Chemokine Receptors
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118037/VUF10132-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118037/
Clinical Information
No Development Reported
CAS Number
1037732-88-9
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