AZ5576

AZ5576 is a potent and highly selective CDK9 inhibitor (IC50: [1][2].

Product Specifications

CAS Number

[2751721-40-9]

UNSPSC

12352005

Target

Apoptosis; CDK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/az5576.html

Purity

99.86

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1C[C@H](NC(C)=O)CCC1)NC2=NC=CC(C3=CC=C(F)C=C3OC)=C2

Molecular Formula

C21H24FN3O3

Molecular Weight

385.43

References & Citations

[1]Bernard Barlaam, et al. Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. |[2]Hashiguchi T, et al., Cyclin-Dependent Kinase-9 Is a Therapeutic Target in MYC-Expressing Diffuse Large B-Cell Lymphoma. Mol Cancer Ther. 2019 Sep;18 (9) :1520-1532.