Alverine (hydrochloride)
Alverine hydrochloride citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.
Product Specifications
CAS Number
5982-87-6
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/alverine-hydrochloride.html
Smiles
CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2.Cl
Molecular Formula
C20H28ClN
Molecular Weight
317.90
References & Citations
[1]Coelho, A.M., et al., Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol, 2001. 53 (10) : p. 1419-26.|[2]Hayase, M., et al., Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol, 2007. 152 (8) : p. 1228-38.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
5-HT1 Receptor
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