Fenitrothion-d6

Fenitrothion-d6 is the deuterium labeled Fenitrothion (HY-B1885) . Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[203645-59-4]

UNSPSC

12352005

Target

Akt; AMPK; Apoptosis; Cholinesterase (ChE) ; Insecticide; Isotope-Labeled Compounds; PI3K; SOD

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Epigenetics; Immunology/Inflammation; Neuronal Signaling; Others; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])([2H])OP(OC1=CC(C)=C(C=C1)[N+]([O-])=O)(OC([2H])([2H])[2H])=S

Molecular Formula

C9H6D6NO5PS

Molecular Weight

283.27

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Abdel-Ghany R, et al. Impact of Exposure to Fenitrothion on Vital Organs in Rats. J Toxicol. 2016;2016:5609734.|[3]Qing Hong, et al. A microcosm study on bioremediation of fenitrothion-contaminated soil using Burkholderia sp. FDS-1. International Biodeterioration &amp Biodegradation