TK-642

TK-642 is a highly active, selective, orally activity SHP2 inhibitor based on pyrazole and pyrazine (IC50=2.7 nmol/L) . TK-642 can effectively inhibit the proliferation of esophageal carcinoma cells and induce cell apoptosis. TK-642 can be used in the study of esophageal cancer[1].

Product Specifications

CAS Number

[2765183-10-4]

UNSPSC

12352005

Target

SHP2

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tk-642.html

Smiles

NCC1(C)CCN(C2=CN=C3C(NN=C3SC4=C(Cl)C=NC=C4)=N2)CC1

Molecular Formula

C17H20ClN7S

Molecular Weight

389.91

References & Citations

[1]Tang K, et al. Discovery of TK-642 as a highly potent, selective, orally bioavailable pyrazolopyrazine-based allosteric SHP2 inhibitor[J]. Acta Pharmaceutica Sinica B, 2024.