TK-642
TK-642 is a highly active, selective, orally activity SHP2 inhibitor based on pyrazole and pyrazine (IC50=2.7 nmol/L) . TK-642 can effectively inhibit the proliferation of esophageal carcinoma cells and induce cell apoptosis. TK-642 can be used in the study of esophageal cancer[1].
Product Specifications
CAS Number
2765183-10-4
UNSPSC
12352005
Target
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tk-642.html
Smiles
NCC1(C)CCN(C2=CN=C3C(NN=C3SC4=C(Cl)C=NC=C4)=N2)CC1
Molecular Formula
C17H20ClN7S
Molecular Weight
389.91
References & Citations
[1]Tang K, et al. Discovery of TK-642 as a highly potent, selective, orally bioavailable pyrazolopyrazine-based allosteric SHP2 inhibitor[J]. Acta Pharmaceutica Sinica B, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
HP213684 200 Reactions
Junctophilin 2 (JPH2) Human qPCR Primer Pair (NM_020433)
Sign In for Pricing
View Details 
MBS2903425 Inquire
Human C1orf106 / Uncharacterized Protein C1orf106 Recombinant Protein
Sign In for Pricing
View Details MBS6338668-01 0.2 mL
Ptf1a, CT (Pancreas transcription factor 1 subunit alpha, Pancreas-specific transcription factor 1a, bHLH transcription factor p48, p48 DNA-binding subunit of transcription factor PTF1, PTF1-p48, PTF1P48) (APC)
Sign In for Pricing
View Details