TK-642
TK-642 is a highly active, selective, orally activity SHP2 inhibitor based on pyrazole and pyrazine (IC50=2.7 nmol/L) . TK-642 can effectively inhibit the proliferation of esophageal carcinoma cells and induce cell apoptosis. TK-642 can be used in the study of esophageal cancer[1].
Product Specifications
CAS Number
[2765183-10-4]
UNSPSC
12352005
Target
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tk-642.html
Smiles
NCC1(C)CCN(C2=CN=C3C(NN=C3SC4=C(Cl)C=NC=C4)=N2)CC1
Molecular Formula
C17H20ClN7S
Molecular Weight
389.91
References & Citations
[1]Tang K, et al. Discovery of TK-642 as a highly potent, selective, orally bioavailable pyrazolopyrazine-based allosteric SHP2 inhibitor[J]. Acta Pharmaceutica Sinica B, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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