Salvicine
Salvicine is a DNA topoisomerase II inhibitor (IC50=3 μM) . Salvicine increases the interaction between DNA and Topo II by interacting with the ATPase domain, inhibiting DNA degradation and ATP hydrolysis. Salvicine has anticancer activities, including inhibiting Topo II, causing DNA damage, overcoming multidrug resistance, and inhibiting tumor cell adhesion[1][2].
Product Specifications
CAS Number
240423-23-8
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/salvicine.html
Smiles
O=C1C(C(C(C)C)=CC2=C1C(CCC(C(C)(C)O)O)=C(C)C=C2)=O
Molecular Formula
C20H26O4
Molecular Weight
330.42
References & Citations
[1]Dey D, et al. Investigating the anticancer potential of salvicine as a modulator of topoisomerase II and ROS signaling cascade[J]. Frontiers in oncology, 2022, 12: 899009.|[2]Meng L, et al. Salvicine, a novel DNA topoisomerase II inhibitor, exerting its effects by trapping enzyme-DNA cleavage complexes[J]. Biochemical pharmacology, 2001, 62 (6) : 733-741.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
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