Palmitoleoyl-CoA (triammonium)

Palmitoleoyl-CoA triammonium is the triammonium salt form of Palmitoleoyl-CoA (HY-137782) . Palmitoleoyl-CoA triammonium can be activated and transported into the mitochondria for metabolism, specifically for β-oxidation. Palmitoleoyl-CoA triammonium induces the cardiac mitochondrial membrane permeability transition, which causes mitochondrial dysfunction. Palmitoleoyl-CoA triammonium regulates metabolism via allosteric control of AMPK β1-isoforms[1][2].

Product Specifications

CAS Number

[1246304-41-5]

UNSPSC

12352204

Target

Biochemical Assay Reagents

Type

Enzyme

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/palmitoleoyl-coa-triammonium.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(OP(O)(OCC(C)([C@H](C(NCCC(NCCSC(CCCCCCC/C=C\CCCCCC)=O)=O)=O)O)C)=O)=O)O[C@H]1N2C3=NC=NC(N)=C3N=C2.N.N.N

Molecular Formula

C37H73N10O17P3S

Molecular Weight

1055.02

References & Citations

[1]Stephen L Pinkosky, et al. Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms. Nat Metab. 2020 Sep;2 (9) :873-881.|[2]Oyanagi E, et al., Palmitoleic acid induces the cardiac mitochondrial membrane permeability transition despite the presence of L-carnitine. Biochem Biophys Res Commun. 2015 Jul 17-24;463 (1-2) :29-36.