SB-237376 (free base)

SB-237376 (free base) is a potassium and calcium channel blocker. SB-237376 (free base) can inhibit the rapidly activating delayed rectifier potassium current I (Kr) (IC50 is 0.42 μM), and at high concentrations, it blocks the L-type calcium current I (Ca, L) . In the rabbit ventricular model, SB-237376 (free base) can induce early afterdepolarizations (EADs) at a concentration of 3 µM. Compared to other IKr inhibitors such as dl-sotalol, SB-237376 has a lower proarrhythmic risk. SB-237376 (free base) holds potential for research in the field of arrhythmia-related diseases[1].

Product Specifications

CAS Number

[179258-59-4]

UNSPSC

12352005

Target

Calcium Channel; Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sb-237376-free-base.html

Smiles

O=C(NCCCNCCC1=CC=C(OC)C(OC)=C1)C2=CC=C([N+]([O-])=O)C=C2

Molecular Formula

C20H25N3O5

Molecular Weight

387.43

References & Citations

[1]Xu X, et al. Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action. J Cardiovasc Pharmacol. 2003 Mar;41 (3) :414-21.