Holothurin A

Product Specifications

CAS Number

[38-26-6]

UNSPSC Description

Holothurin A is a potent inhibitor against BCL2, HDAC1 and PTPN2 with an anticancer activity, which is derived from sea cucumber Holothuria scabra. Holothurin A plays an essential role in the process of apoptosis, cell cycle and suppressing tumor[1].

Target Antigen

Bcl-2 Family; HDAC; Phosphatase

Type

Natural Products

Related Pathways

Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/holothurin-a.html

Smiles

C[C@]12[C@]3([C@H](C=C4[C@@]2([H])CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@@H](CO6)OS(=O)(O[Na])=O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O[C@H]9[C@@H]([C@H]([C@@H]([C@H](O9)CO)O)OC)O)O)O)O)C)O)[C@@]([C@@](OC3=O)([C@]%10([H])CCC(C)(O%10)C)C)(CC1)O

Molecular Weight

1221.29

References & Citations

[1]Wargasetia T L, et al. Anticancer potential of holothurin A, holothurin B, and holothurin B3 from the sea cucumber Holothuria scabra[C]//AIP Conference Proceedings. AIP Publishing, 2020, 2231(1).