TSPO ligand-1
Product Specifications
UNSPSC Description
TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration[1][2].
Target Antigen
Autophagy; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Autophagy;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Others
Assay Protocol
https://www.medchemexpress.com/tspo-ligand-1.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C(C1=C(C2=CC=CC=C2)NC3=C1C=CC=C3)=O)Cl
Molecular Weight
283.71
References & Citations
[1]Takahashi D, et, al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.|[2]Tina Notter, et al. Neuronal activity increases translocator protein (TSPO) levels. Mol Psychiatry. 2021 Jun;26(6):2025-2037. doi: 10.1038/s41380-020-0745-1. Epub 2020 May 12.|[3] Benjamin B Tournier, et al. Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer's Disease. J Alzheimers Dis. 2020;77(3):1043-1056. doi: 10.3233/JAD-200136.|[4]Lan N Tu, et al. Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells. Endocrinology. 2016 Mar;157(3):1110-21. doi: 10.1210/en.2015-1795. Epub 2016 Jan 7.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150407/TSPO-ligand-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150407/TSPO-ligand-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
4560-08-1
Available Sizes
Curated Selection
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