TSPO ligand-1
TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration[1][2].
Product Specifications
CAS Number
[4560-08-1]
UNSPSC
12352005
Hazard Statement
H301-H311-H314-H331
Target
Autophagy; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Others
Assay Protocol
https://www.medchemexpress.com/tspo-ligand-1.html
Purity
98.0
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C(C1=C(C2=CC=CC=C2)NC3=C1C=CC=C3)=O)Cl
Molecular Formula
C16H10ClNO2
Molecular Weight
283.71
Precautions
P260-P264-P270-P271-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P403+P233-P405-P501
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
