TSPO ligand-1

TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration[1][2].

Product Specifications

CAS Number

[4560-08-1]

UNSPSC

12352005

Hazard Statement

H301-H311-H314-H331

Target

Autophagy; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease; Others

Assay Protocol

https://www.medchemexpress.com/tspo-ligand-1.html

Purity

98.0

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C(C1=C(C2=CC=CC=C2)NC3=C1C=CC=C3)=O)Cl

Molecular Formula

C16H10ClNO2

Molecular Weight

283.71

Precautions

P260-P264-P270-P271-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P403+P233-P405-P501

References & Citations

[1]Takahashi D, et, al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76 (5) :797-810.e10.|[2]Tina Notter, et al. Neuronal activity increases translocator protein (TSPO) levels. Mol Psychiatry. 2021 Jun;26 (6) :2025-2037. doi: 10.1038/s41380-020-0745-1. Epub 2020 May 12.|[3] Benjamin B Tournier, et al. Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer's Disease. J Alzheimers Dis. 2020;77 (3) :1043-1056. doi: 10.3233/JAD-200136.|[4]Lan N Tu, et al. Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells. Endocrinology. 2016 Mar;157 (3) :1110-21. doi: 10.1210/en.2015-1795. Epub 2016 Jan 7.