Propyl gallate

Propyl gallate is a common food antioxidant. Propyl gallate can inhibit the production of acrolein, glyoxal and methylglyoxal. Propyl gallate exhibits anti-inflammatory, antitumor and cardioprotective activities[1][2][3][4].

Product Specifications

CAS Number

[121-79-9]

UNSPSC

12352005

Hazard Statement

H317, H318

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/propyl-gallate.html

Purity

99.85

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(OCCC)C1=CC(O)=C(O)C(O)=C1

Molecular Formula

C10H12O5

Molecular Weight

212.20

Precautions

H317, H318

References & Citations

[1]Cui H, et al. Dual effects of propyl gallate and its methylglyoxal adduct on carbonyl stress and oxidative stress. Food Chem. 2018 Nov 1;265:227-232.|[2]Wang J, et al. Scavenging of Acrolein by Food-Grade Antioxidant Propyl Gallate in a Model Reaction System and Cakes. J Agric Food Chem. 2019 Aug 7;67 (31) :8520-8526.|[3]Park WH. Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathione. Sci Rep. 2024 Mar 5;14 (1) :5375.|[4]Park WH. Propyl gallate reduces the growth of lung cancer cells through caspase‑dependent apoptosis and G1 phase arrest of the cell cycle. Oncol Rep. 2020 Dec;44 (6) :2783-2791.|[5]Du CK, et al., In vivo effects of propyl gallate, a novel Ca (2+) sensitizer, in a mouse model of dilated cardiomyopathy caused by cardiac troponin T mutation. Life Sci. 2014 Jul 25;109 (1) :15-9.