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STAT3-IN-39

STAT3-IN-39 (compound 10K) is an orally active STAT3 inhibitor that exhibits excellent inhibitory activity against STAT3 phosphorylation, with an IC50 of 0.47 μM in NIH-3T3 cells. STAT3-IN-39 inhibits the TGF-β1-induced fibrotic response and blocks the epithelial-mesenchymal transition in A549. STAT3-IN-39 can be utilized in research related to idiopathic pulmonary fibrosis[1].

Product Specifications

CAS Number

3037596-35-0

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/stat3-in-39.html

Smiles

O=C(C1=CC2=CC=CC=C2S1(=O)=O)N3CCN(CC4=CC(F)=C(F)C=C4F)CC3

Molecular Formula

C20H17F3N2O3S

Molecular Weight

422.42

References & Citations

[1]Wang Y, et al. Discovery of the novel Benzo[b]thiophene 1,1-dioxide derivatives as a potent STAT3 inhibitor against idiopathic pulmonary fibrosis. Eur J Med Chem. 2023 Jan 15;246:114953.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

STAT3

Frequently Asked Questions

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