Human APEX1 Protein

<strong>Human APEX1 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011745_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> APEX nuclease (multifunctional DNA repair enzyme) 1 protein, APE protein, APE1 protein, APEN protein, APX protein, HAP1 protein, REF-1 protein, REF1_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Coughlin SS. Epidemiology of Breast Cancer in Women Adv Exp Med Biol. 2019;1152:9-29._x000D_ 2: Faruk MO, Ichimura Y, Komatsu M. Selective autophagy Cancer Sci. 2021 Oct;112(10):3972-3978._x000D_ 3: Zhao CR, Yang FF, Cui Q, Wang D, Zhou Y, Li YS, Zhang YP, Tang RZ, Yao WJ, Wang X, Pang W, Zhao JN, Jiang ZT, Zhu JJ, Chien S, Zhou J. Vitexin inhibits APEX1 to counteract the flow-induced endothelial inflammation Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2115158118._x000D_ 4: Kim DV, Kulishova LM, Torgasheva NA, Melentyev VS, Dianov GL, Medvedev SP, Zakian SM, Zharkov DO. Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line PLoS One. 2021 Sep 16;16(9):e0257473._x000D_ 5: Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets Mol Cell. 2019 Mar 7;73(5):885-899.e6._x000D_ 6: Wang C, Tang M, Chen Z, Nie L, Li S, Xiong Y, Szymonowicz KA, Park JM, Zhang H, Feng X, Huang M, Su D, Hart T, Chen J. Genetic vulnerabilities upon inhibition of DNA damage response Nucleic Acids Res. 2021 Aug 20;49(14):8214-8231._x000D_ 7: Hewitt G, Borel V, Segura-Bayona S, Takaki T, Ruis P, Bellelli R, Lehmann LC, Sommerova L, Vancevska A, Tomas-Loba A, Zhu K, Cooper C, Fugger K, Patel H, Goldstone R, Schneider-Luftman D, Herbert E, Stamp G, Brough R, Pettitt S, Lord CJ, West SC, Ahel I, Ahel D, Chapman JR, Deindl S, Boulton SJ. Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD Mol Cell. 2021 Feb 18;81(4):767-783.e11._x000D_ 8: Yang J, Yang D, Cogdell D, Du X, Li H, Pang Y, Sun Y, Hu L, Sun B, Trent J, Chen K, Zhang W. APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival Technol Cancer Res Treat. 2010 Apr;9(2):161-9._x000D_ 9: Zhang Y, Xie X, Yeganeh PN, Lee DJ, Valle-Garcia D, Meza-Sosa KF, Junqueira C, Su J, Luo HR, Hide W, Lieberman J. Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2022830118._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33502561">10: Tan A, Ruan P, Sun P. APEX1/miR-24 axis: a promising therapeutic target in endometriosis Arch Gynecol Obstet. 2021 Jul;304(1):131-141. </a>_x000D_ _x000D_ <strong>Products Related to Human APEX1 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>