Strictosidinic acid

Strictosidinic acid, an orally active glycoside indole monoterpene alkaloid isolated from Psychotria myriantha leaves, inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral analgesic and antipyretic activities in mice[1][2].

Product Specifications

CAS Number

[150148-81-5]

UNSPSC

12352005

Target

5-HT Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/strictosidinic-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CO[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)[C@H](C=C)[C@@H]1C[C@@H]3NCCC4=C3NC5=C4C=CC=C5)O

Molecular Formula

C26H32N2O9

Molecular Weight

516.54

References & Citations

[1]F M Farias, et al. Strictosidinic Acid, Isolated From Psychotria Myriantha Mull. Arg. (Rubiaceae), Decreases Serotonin Levels in Rat Hippocampus. Fitoterapia. 2012 Sep;83 (6) :1138-43.|[2]F M Farias, et al. Monoamine Levels in Rat Striatum After Acute Intraperitoneal Injection of Strictosidinic Acid Isolated From Psychotria Myriantha Mull. Arg. (Rubiaceae) . Phytomedicine. 2010 Mar;17 (3-4) :289-91.