Alisol A (Standard)

Alisol A (Standard) is the analytical standard of Alisol A (HY-N0853) . This product is intended for research and analytical applications. Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8) . Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[19885-10-0]

UNSPSC

12352211

Target

Acetyl-CoA Carboxylase; AMPK; Interleukin Related; MMP; PPAR; Reference Standards

Type

Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Infection; Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/alisol-a-standard.html

Smiles

C[C@]([C@@]1(C2=C([C@H](C)C[C@H](O)[C@@H](O)C(C)(O)C)CC1)C)(CC[C@@]3([H])C4(C)C)[C@]([C@H](C2)O)([H])[C@]3(CCC4=O)C

Molecular Formula

C30H50O5

Molecular Weight

490.72

References & Citations

[1]Yu Y, et al.In vitro metabolism of alisol A and its metabolites' identification using high-performance liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Dec 15;941:31-7.|[2]Yu Y, et al. A sensitive liquid chromatography-mass spectrometry method for simultaneous determination of alisol A and alisol A 24-acetate from Alisma orientale (Sam.) Juz. in rat plasma. Anal Bioanal Chem. 2011 Jan;399 (3) :1363-9