Bexotegrast (hydrochloride)
Bexotegrast hydrochloride (PLN-74809 hydrochloride) is a small molecule dual selective inhibitor with activity targeting αVβ1 and αVβ6. Bexotegrast hydrochloride is used for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC) . Bexotegrast hydrochloride inhibits the activation of TGF-β1 by blocking the function of these integrins, thereby preventing the growth of fibrous tissue in the lungs and bile ducts[1].
Product Specifications
CAS Number
2775365-40-5
Product Name Alternative
PLN-74809 (hydrochloride)
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bexotegrast-hydrochloride.html
Smiles
COCCN(CCCCC(N1)=CC=C2C1=NCCC2)CC[C@@H](C(O)=O)NC3=NC=NC4=C3C=CC=C4.Cl.Cl
Molecular Formula
C27H38Cl2N6O3
Molecular Weight
565.54
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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