CFTR potentiator 1

CFTR potentiator 1 (I1421) is a potent CFTR potentiator with an EC50 value of 64 nM. CFTR potentiator 1 allosterically activates a wide range of CF-causing mutants, such as ΔF508 and G551D CFTR[1].

Product Specifications

UNSPSC

12352005

Target

CFTR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cftr-potentiator-1.html

Smiles

NC1=NN(C([C@@H](COC2=CC=CC=C2)C)=O)C3=CC(C(N)=O)=CC=C31

Molecular Formula

C18H18N4O3

Molecular Weight

338.36

References & Citations

[1]Fangyu Liu, et al. Structure-based discovery of CFTR potentiators and inhibitors. Cell. 2024 May 23:S0092-8674 (24) 00472-0.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

50852091 4x 500 ng

ZFP14-set siRNA/shRNA/RNAi Lentivector (Human)

Ask

View Details

V2143 1 mg

Vitamin K1-18O_x000B_ (Mixture of 1-18O and 4-18O) (2-Methyl-3-[ (2E,7R,11R) -3,7,11,15-tetramethyl-2-hexadecenyl]-1,4-naphthalene-dione-18O, Vitamin K1-18O, Phytonadione-18O)

Ask

View Details

CABT-CS700 100 μl

Magic™ Rabbit Anti-ASFV p54 Monoclonal Antibody, Clone IM2397

Ask

View Details

NBP2-61559 100 µg

Rabbit Monoclonal Histone H4 [ac Lys20] Antibody (205)

Ask

View Details

323217 100 µL

MARCH4 discontinued

Ask

View Details

MBS9206369-01 0.08 mL

UGT2A3 Antibody (Center)

Ask

View Details