Anti-Nerve Growth Factor Receptor (NGFR) Antibody

Mouse Monoclonal Antibody specific to Nerve Growth Factor Receptor (NGFR)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD antigen CD271

Gene Name

NGFR

NCBI Gene ID

UniProt

P08138

Cellular Locus

Cell membrane, Perikaryon, Cell projection, growth cone, Cell projection, dendritic spine

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human NGFR.

Target Antigen

Tumor necrosis factor receptor superfamily member 16

Target

Nerve Growth Factor Receptor (NGFR)

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

IHC

Field of Research

Cancer research

Purification Method

Purified by immunoaffinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Tris

Function

Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). {UniProtKB:Q9Z0W1, PubMed:14966521, PubMed:23785138, PubMed:24908487, PubMed:26646181, PubMed:3022937}.

Additionnal Information

<br><br>Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

Human NGFR. Reactivity with other species has not been investigated.

Formulation

Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.

Buffer pH

pH 7.3-7.7

Target Background

Nerve Growth Factor Receptor (NGFR), also known as p75, P-75NTR or CD271, is a neurotrophin receptor belonging to the tumor necrosis factor receptor family. NGFR is expressed on Schwann cells and neurons as well as a number of other non-neuronal cell types, and it functions during central and peripheral nervous system development to regulate neuronal growth, migration, differentiation, and cell death. Nerve Growth Factor Receptor is also expressed on melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurobromas, neurotized nevi (type C melanocytes), and other neural crest cell or tumor derivatives.