Cyproheptadine

Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders[1][2].

Product Specifications

CAS Number

[129-03-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

5-HT Receptor; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/cyproheptadine.html

Purity

99.92

Solubility

DMSO : 3.17 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 60°C)

Smiles

CN1CC/C(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C/24

Molecular Formula

C21H21N

Molecular Weight

287.40

Precautions

H315, H319, H335

References & Citations

[1]Calka O, et, al. Effect of cyproheptadine on serum leptin levels. Adv Ther, 2005. 22 (5) : p. 424-8.|[2]Olivia A Lin, et al. The Antidepressant 5-HT2A Receptor Antagonists Pizotifen and Cyproheptadine Inhibit Serotonin-Enhanced Platelet Function. PLoS One. 2014; 9 (1) : e87026.|[3]Iwaki M, et al. Pharmacokinetics of cyproheptadine and its metabolites in rats. Biol Pharm Bull. 1993 Dec;16 (12) :1276-81. |[4]Codd EE, et al. Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine. Toxicol Sci. 2010 Oct;117 (2) :493-504.|[5]Wold JS, et al. Species dependent pancreatic islet toxicity produced by cyproheptadine: alterations in beta cell structure and function. Toxicol Appl Pharmacol. 1971 Jun;19 (2) :188-201.|[6]Padrid PA, et al. Cyproheptadine-induced attenuation of type-I immediate-hypersensitivity reactions of airway smooth muscle from immune-sensitized cats. Am J Vet Res. 1995 Jan;56 (1) :109-15. Erratum in: Am J Vet Res 1995 Mar;56 (3) :402.